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Bsense Bio Therapeutics
Sensory Neurons

About Us

Electrophysiolofical recording pipette

Bsense Bio’s approach is based on the targeting of two cation channels, a ligand-gated cation channel and a voltage-gated potassium channel, respectively, TRPV1 and Kv7.2/3, which are co-localized on sensory nociceptive neurons and are widely recognized as prominent players in the modulation of neuronal excitability. This dual activity unique approach boosts potency while providing safe and non-addictive new therapeutic potential. The company has generated preclinical proof-of-concept in several chronic pain models and Tinnitus.

Bsense Bio Therapeutics

Bsense Bio Therapeutics is developing small molecules for treating sensory hyperexcitability related disorders.

 

Bsense is pioneering a novel approach targeting multiple hyperexcitability related mechanisms using a single compound, in order to achieve greater efficacy and safety.

Electrophysiolofical recording pipette
Electrophysiolofical recording pipette

Our Team

Dori Pelled, PhD

Dori Pelled, PhD

Chief Executive Officer

Dr. Pelled is a senior biopharmaceutical executive with over two decades of experience in drug development. Before co-establishing INDoors Medical Development, he served for 5 years as the Chief Operating Officer at IMEL Biotherapeutics that develops cell-based therapy for the treatment of genetic diseases & age-related indications. Previously, he was the Vice President of Research & Development at the rare genetic diseases company Eloxx Pharmaceuticals (NASDAQ:ELOX). Earlier, he was Director of Preclinical Research at the orphan indications company Chiasma Pharmaceuticals (NASDAQ:CHMA; acquired by Amryt Pharma, NASDAQ: AMYT) and Chief Technology Officer and Director of Clinical Development at the lipid-based products company Enzymotec (NASDAQ:ENZY; acquired by Frutarom, LSE:FRUT/TASE:FRUT). Dr. Pelled earned his MSc and BSc degrees in Clinical Biochemistry and Chemistry from Tel-Aviv University, Israel, and PhD in Biochemistry from the Weizmann Institute of Science, Israel. He is a co-author of 25 peer reviewed publications and co-inventor of 17 patents
Shmuel Tuvia, PhD

Shmuel Tuvia, PhD

Chief Development Officer

Dr. Tuvia is a senior biopharmaceutical executive with >25-years of experience. Before co-establishing INDoors Medical Development, he served as Chief Scientist Officer at the clinical-stage oncology company Ayala Pharm (NASDAQ:ADXS), Chief Development Officer at Ukko, developing building a comprehensive, clinically validated map of the molecular structure of food allergies, Chief Innovation Officer at FutuRx, an incubator, founded by J&J, Takeda, and OrbiMed, the Chief Operating Officer at Eloxx (NASDAQ:ELOX) that develops novel small molecule medicines to treat rare and ultra-rare genetic diseases, Vice President Preclinical at Chiasma Pharmaceuticals (NASDAQ: CHMA), where he headed preclinical development and pharmacology of oral octreotide through the NDA submission (Mycapssa®). Dr Tuvia earned his MSc and BSc degrees in biology from Tel-Aviv University, Israel, and his Ph.D. with Distinction at the Sackler School of Medicine at Tel-Aviv University, Israel and postdoc studies at Duke University. He is a co-author of 20 peer reviewed publications and co-inventor of 12 patents
Adi Raveh, PhD.

Adi Raveh, PhD.

VP Research

Dr. Raveh has over 20 years of experience in neurobiology, with deep expertise in ion channel pharmacology, GPCR biology, and chronic pain mechanisms. As a founding member of Bsense, he has led the company’s drug research and development program from its inception, integrating electrophysiology, pharmacology, and translational models to advance novel therapeutics. As VP Research, Dr. Raveh oversees scientific strategy, discovery pipeline progression, and cross-functional R&D operations. His track record includes developing high-content pharmacological screening platforms, guiding structure–activity relationship campaigns, and advancing multiple candidates toward clinical readiness. Dr. Raveh received his Ph.D. in Biology from the Weizmann Institute of Science, specializing in ion channel biophysics and physiology. He conducted postdoctoral research at the Department of Biomedicine, University of Basel, Switzerland, investigating GPCR signaling and Alzheimer’s disease mechanisms.

Board of Directors

Silvia Noiman, PhD, MBA

Silvia Noiman, PhD, MBA

Executive Chairperson

Dr. Noiman is a serial entrepreneur and leading executive with over 30 years’ experience in the Life Science industry. She has been a venture partner at Pontifax and founded many of Pontifax’s portfolio companies. Dr. Noiman was the founder, Chair and Chief Executive Officer of IMEL Biotherapeutics between 2019-2024. In 2013, she founded the rare diseases company Eloxx Pharmaceuticals (NASDAQ:ELOX) and served as the CEO from inception to a successful IPO (2018). Previously, she chaired the immuno-oncology company cCAM Biotherapeutics (acquired by Merck). She also founded and served as Senior Vice President of the computational drug design company Predix (NASDAQ, EPIX). Dr. Noiman holds a Ph.D. in Molecular Biology and an MBA from Tel Aviv University and did her post-doc studies at the Weizmann Institute of Science.
Assaf Keret

Assaf Keret

BOD Member

Mr. Keret holds more than 15 years of financial consulting, investment banking, and project management experience. He focuses mainly on the corporate finance aspects of RMG’s Life Science practice. Prior to joining RMG, Mr. Keret worked at Swary Financial Consulting, a prominent Israeli boutique financial advisory firm, leading valuation projects for some of Israel’s largest companies. Prior to joining Swary, he worked as a financial consultant in the Deloitte Transactional Services team in Tel Aviv. Mr. Keret is a CPA, and holds an LLM, and a BA in Law and Accounting from the Interdisciplinary Center (IDC), Herzliya.
Yaron Breski

Yaron Breski

BOD Member

Mr. Breski holds over 15 years of experience in healthcare, business development, strategic consulting, and general management. Mr. Breski has been working on developing the strategy behind innovative investment models, which bring new approaches to financing in today’s healthcare environment. Previously, he served as a senior executive of business development at Rosetta Genomics, was part of the US Strategic Planning group at Novartis, and worked within Booz Allen’s Healthcare group in New York. Mr. Breski holds a B.Sc. in Biology from Tel Aviv University and an MBA from The Wharton School.

Scientific Advisors

Alan D. Brown, PhD.

Alan D. Brown, PhD.

MedChem

Alan is a medicinal chemist who has worked for over 30 years in the pharma industry. He has worked across a wide range of projects and disease areas, including roles such as Exploratory and Therapeutic Area Head of Chemistry (Sexual Health, Pain, and Sensory Disorders Research Units) with Pfizer and Head of Chemistry at Benevolent AI. Alan is vastly experienced across hit generation, lead optimisation and candidate identification and has been personally involved in 20 projects which have resulted in new medicines being tested in humans. He is author/ named inventor on >80 patents and peer reviewed publications.
Jeffrey D. Kennedy, PhD.

Jeffrey D. Kennedy, PhD.

Preclinical Development

Jeffrey D. Kennedy, Ph.D. spent over 3 decades in the pharmaceutical industry working for major pharma or serving as a pharmaceutical consultant and is internationally recognized as an expert in pain pathophysiology and neuroinflammation. Following training as an immunologist and early work in the pulmonary inflammation/asthma field, Dr. Kennedy adapted this knowledge base to the neuroscience field where, as part of a 16 year career at Wyeth Research, he led pain drug discovery for Wyeth Neuroscience. He then spent 5 years at Eli Lilly and Co., where he led a behavioral pharmacology group that provided broad support to the pain and larger neuroscience therapeutic area while also serving as company representative to the EF7 IMI public-private partnership and steering committee member for the Europain consortium in addition to helping facilitate broader company partnering efforts. Since leaving pharma, Dr. Kennedy, in addition to private consulting work, has held long-term roles as grant reviewer for NINDS and as member of both NIH and FDA committees tasked with helping improve the success of pain translational R&D efforts.
Vladimir Skljarevski, M.D.

Vladimir Skljarevski, M.D.

Clinical Development

Dr. Vladimir (Vlad) Skljarevski brings more than 25 years of leadership and global neuroscience drug development experience across all phases of clinical research in academia, big pharma, and small biotech companies. As a global medical leader at Eli Lilly and Company, he designed and conducted over 20 large Phase 2 and Phase 3 trials which represented the basis for the worldwide registration of two products – Cymbalta for chronic pain, and Emgality for migraine prevention. He has an extensive regulatory, clinical operations, business development, and partnership building experience within the US, the EU, Japan, and China. More recently, he has been engaged full-time in providing consulting services for both big pharma and small biotech companies operating in the space of pain, neurodevelopmental disorders and neurodegeneration. Dr. Skljarevski holds an MD degree from the University of Sarajevo in his native Bosnia and Herzegovina (former Yugoslavia). He is a fully trained neurosurgeon with a subspecialty training in stereotactic neurosurgery from Karolinska Hospital in Stockholm, Sweden. He also completed a neurology residency at the University of Vermont in Burlington, VT, as well as a clinical fellowship in cerebrovascular diseases at the University of Ottawa in Canada. Vlad holds an active medical license in the State of Indiana and serves as a member of the US NIH external oversight committee of the HEAL (Helping to End Addiction Long-term) project.
Michael Mizhiritskii, PhD.

Michael Mizhiritskii, PhD.

CMC

Over 40 years activity in organic chemistry both in research and industry. Chief chemist of several companies. Independent adviser in organic chemistry, CMC and Medical chemistry since 2007 to companies in Israel, USA, Europe and Asia. Has played key roles in many projects for pharma, agrochemical, biotechnology, “Green chemistry” and “Biofuel” companies.

Collaborators

Inventors

Investors

Steve Davidson , PhD

Associate Professor

Prof. Bernard Attali

Prof. Bernard Attali

Inventor

Professor, Department of Physiology & Pharmacology, Sackler Faculty of Medicine, Tel Aviv University. Prof. Attali is the inventor of the technology and as such serve as a consultant to the company. Prof. Attali published over 100 research papers in leading journals in his field. In addition, he was awarded several awards, including the Israel Cancer Research Fund and the Shtacher award from the Tel-Aviv University.
Asher Peretz, PhD.

Asher Peretz, PhD.

Co-Inventor

Department of Physiology & Pharmacology, Sackler Faculty of Medicine, Tel Aviv University. Dr. Asher Peretz holds a Ph.D from the Hebrew University of Jerusalem. He is a co-inventor of the technology and will share his comprehensive knowledge and experience in the field of electrophysiology of ion channels.
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